Vein filter cartridge

ABSTRACT

A cartridge for holding a vessel filter and connectable to a component of a delivery system comprising a housing having a first end and a second end, and an engagement member movable to a first engageable position to engage the component of a delivery system to connect the cartridge to the component in a first orientation. A control member is preferably operatively associated with the engagement member to move the engagement member to the first engageable position.

BACKGROUND

1. Technical Field

This application relates to delivery of a vascular filter for capturing blood clots and more particularly to a cartridge containing a vein filter for mounting to a component of a delivery system.

2. Background of Related Art

Passage of blood clots to the lungs is known as pulmonary embolism. These clots typically originate in the veins of the lower limbs and can migrate through the vascular system to the lungs where they can obstruct blood flow and therefore interfere with oxygenation of the blood. Pulmonary embolisms can also cause shock and even death.

In some instances, blood thinning medication, e.g. anticoagulants such as Heparin, or sodium warfarin can be given to the patient. These medications, however, have limited use since they may not be able to be administered to patients after surgery or stroke or given to patients with high risk of internal bleeding. Also, this medication approach is not always effective in preventing recurring blood clots.

Therefore, surgical methods to reduce the likelihood of such pulmonary embolisms by actually blocking the blood clot from reaching the lungs have been developed. One surgical method of treatment involved major surgery where the size of the vessel lumen was restricted by placement of ligatures or clips around the vein, e.g. the inferior vena cava which transports blood from the lower portion of the body to the heart and lungs. This prevented passage of dangerously large blood clots through the vein to the lungs. However, this approach is an invasive surgical procedure, requiring an abdominal incision and general anesthesia and frequently causing vessel thrombosis and lower extremity swelling. Also, there is a lengthy patient recovery time and additional hospital and surgeon expenses associated with this major surgery. In fact, oftentimes, the patients requiring the surgery are unhealthy and the major surgery and general anesthesia poses a risk in and of itself.

To avoid such invasive surgery, less invasive surgical techniques have been developed. These involve the placement of a mechanical barrier in the inferior vena cava. These barriers are in the form of filters and are typically inserted through either the femoral vein (femoral approach) in the patient's leg or the arm or right jugular vein in the patient's neck (jugular approach) under local anesthesia. The filters are then deployed intravascularly in the inferior vena cava where they expand to block migration of the blood clots from the lower portion of the body to the heart and lungs.

Since numerous filters which can be inserted via both the femoral and jugular approaches have a filtering portion downstream of a mounting (anchoring) portion, the surgeon must ensure that the filter is placed in the correct orientation so that the filtering portion is positioned to capture blood clots. Insertion and placement in the wrong orientation would cause the filter to be inoperative and could cause thrombosis. With certain filters, the wrong orientation could result in the anchoring features of the filter failing to grasp the vessel, resulting in migration of the filter to the central venous vasculature which could cause obstruction, vessel perforation, dysrhythmia or even death.

One attempt to orient the filter in the proper position is the cartridge being marketed by Cordis for placement of its Optease* vena cava filter. The cartridge, which contains the filter inside, has arrows labeled jugular or femoral to designate the direction to attach via snap fit the cartridge to the delivery instrument. However, if improper attention is paid by the user to the arrows, the user could easily attach the cartridge to the delivery instrument in the incorrect orientation, causing the problems enumerated above.

B. Braun markets another cartridge for delivery of their Vena Tech* filter. The cartridge has a femoral end colored red and a jugular end colored blue. A corresponding red pusher and blue pusher are provided which can only fit into the respective ends of the cartridge. The selected pusher is intended to be inserted into the cartridge prior to mounting of the cartridge to the delivery instrument However, the surgeon can mistakenly mount the cartridge in the wrong orientation by threading the cartridge first onto the delivery system (in the wrong orientation), and then inserting the pusher.

In U.S. Pat. No. 6,328,755, a filter cartridge is disclosed with a hinged locking mechanism. Orientation of the cartridge is not addressed.

In commonly assigned co-pending patent application Ser. No. 10/889,429, filed Jul. 12, 2004, a cartridge is disclosed with a pair of locking rails engaged by a detent to hold the cartridge in place. Markings on the cartridge indicate the jugular or femoral orientation. However, this cartridge suffers from the disadvantages enumerated above since the surgeon must rely solely on the markings for cartridge orientation.

It would be advantageous to provide a filter cartridge which is easily mounted to a delivery system component and which reduces the chances of being loaded in the incorrect orientation. Such cartridge could advantageously be used to load various types of filters. It could also be used to load various vascular devices.

SUMMARY

The present invention overcomes the problems and deficiencies of the prior art. The present invention provides a cartridge for holding a vessel filter which is connectable to a component of a delivery system. The cartridge comprises a housing having an engagement member movable to a first engageable position to engage the component of the delivery system to connect the cartridge to the component in a first orientation. A control member is operatively associated with the engagement member to move the engagement member to the engageable position.

In a preferred embodiment, a non-engageable position of the engagement member corresponds to a retracted position of the engagement member and the engageable position corresponds to an extended position of the engagement member.

The cartridge preferably includes a second engagement member movable to a second engageable position to engage the component of the delivery system to connect the cartridge to the component in a second orientation. In a preferred embodiment, the first and second engagement members are on opposing end portions of a sliding member. In one embodiment, the control member is movable in a first direction to move the engagement member to the first engageable position to connect the cartridge in the first orientation and movable in a second different direction to move the second engagement member to the second engageable position to connect the cartridge in a second orientation.

The control member preferably comprises a post movable (e.g. slidable) within an opening in the housing, with the opening preferably including retention structure (e.g. a detent) to retain the post in a neutral position corresponding to the first non-engageable position of the engagement member. In one embodiment, the opening has an axial component and a radial component wherein the post is positioned in the radial component to retain the engagement member in the engageable position.

In one embodiment, the engagement member includes a snap fit feature exposed in the first engageable position to snap fit with the component of the delivery system.

The present invention also provides a vessel filter delivery system comprising

a) a cartridge having

-   -   a housing having a first end corresponding to a jugular delivery         orientation and a second end corresponding to a femoral delivery         orientation, the housing dimensioned for retaining a filter,     -   a first engagement member movable to a first engageable position         for connection of the cartridge for jugular delivery         orientation;     -   a second engagement member movable to a second engageable         position for connection of the cartridge for femoral delivery         orientation;

b) a vessel filter positioned within the cartridge;

c) a delivery tube: and

d) a pusher for advancing the vessel filter from the cartridge and through the delivery tube.

The cartridge may further include indicia on the housing to indicate the femoral and jugular orientations.

In one embodiment, a wire extends from the pusher to separate retention hooks of the filter during delivery.

The engagement members preferably have a snap fit feature for connection of the cartridge in the engageable position. A control member is preferably provided for moving the engagement member having a post movable within an opening formed in the housing. A retention structure could be provided to retain the post in at least one of the positions of the engagement member.

The present invention further provides a method of connecting a vessel filter to a component of a delivery system for delivering the vessel filter to a patient, the method comprising:

providing a cartridge dimensioned to contain a filter;

determining whether a jugular approach or femoral approach for filter insertion is desired;

orienting the cartridge to correspond to the approach determined; and

moving an engagement member to a connection position for connection of the cartridge to a component of the delivery system.

In a preferred embodiment, the step of moving the engagement member preferably comprises the step of moving a control member extending from the cartridge to move the engagement member from a retracted position substantially within the cartridge. The cartridge can contain indicia to indicate a femoral and jugular orientation of the cartridge, and the step of moving the control member preferably comprises moving the engagement member in the direction indicated by the indicia. The cartridge is preferably connected to a hub of an introducer sheath component of the delivery system.

BRIEF DESCRIPTION OF THE DRAWINGS

Preferred embodiment(s) of the present disclosure are described herein with reference to the drawings wherein:

FIG. 1 is a perspective view of the vessel filter cartridge of the present invention;

FIG. 2 is a longitudinal cross-sectional view taken along line 2-2 of FIG. 1;

FIG. 3 is an exploded view of the cartridge;

FIG. 4 is a perspective view of the cartridge illustrating the knob being moved from its neutral position in a first direction to expose the engagement member for a femoral delivery approach;

FIG. 5 is a broken perspective view of the introducer sheath and pusher of the delivery system and a perspective view of the cartridge prior to connection to the hub of the sheath, wherein the cartridge is shown with the knob in the first extended position to fully expose the engagement member for femoral orientation and connection;

FIG. 6 is a perspective view showing the cartridge of FIG. 5 attached to the hub of the sheath of the delivery system;

FIG. 7 is a longitudinal cross-sectional view taken along line 7-7 of FIG. 6;

FIG. 8A illustrates delivery of the filter via a femoral approach;

FIG. 8B illustrates placement of the filter in the inferior vena cava;

FIG. 9 is a longitudinal cross-sectional view similar to FIG. 7 except showing the knob moved in a second direction to a second extended position to expose the engagement member from an opposing side of the cartridge for a jugular delivery approach;

FIGS. 10A and 10B illustrate perspective views of the cartridge showing the position of the knob and engagement member for the jugular approach;

FIG. 11A illustrates delivery of the filter via the jugular approach;

FIG. 11B illustrates placement of the filter in the inferior vena cava;

FIG. 12A is a perspective view of one filter which can be inserted using the cartridge of the present invention;

FIG. 12B is a perspective view of the filter of FIG. 12A shown in the collapsed position;

FIG. 12C is a close-up side view of the retention hooks of the filter of FIG. 12B;

FIG. 13A is a side view of another filter which can be inserted using the cartridge of the present invention;

FIG. 13B is a side view of the filter of FIG. 13A shown in the collapsed position; and

FIGS. 14 and 15 are perspective views of other filters in the prior art which can be inserted using the cartridge of the present invention.

DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS

Turning now to the drawings, wherein like reference numerals identify similar or like components throughout the several views, a delivery system for delivery and placement of a vein filter is disclosed. The system includes a cartridge containing the filter which is mounted to a component of the delivery system. Since the surgeon can deliver the filter to the vessel using either a femoral approach (through the femoral vein in the leg) or a jugular approach (through the jugular vein in the neck), the cartridge of the present invention is designed to facilitate the correct orientation of the cartridge so that the filter is delivered to the vessel in the correct orientation. This is achieved not only through the provision of visual indicators on the cartridge but by a sliding mechanism in the cartridge which needs to be moved by the user in order to mount the cartridge to the delivery system component.

Turning now to the details of the cartridge of the invention, with reference to FIGS. 1-4, cartridge 10 has a housing 12, a slide 30 slidably received within housing 12, a tube 40 and a knob 16. Formed within housing 12 is an opening 20, preferably in the form of a slot, which has a longitudinal component 22, a first radial component 24 and a second radial component 26. Post 18 of knob 16 slides within opening 20 as described in more detail below. A filter 900, corresponding to the filter of FIG. 12, is shown within tube 40 by way of example. As will become apparent from the discussion below, other filters can be contained in the cartridge 10.

Slide 30 contains an aperture 39 to receive post 18 of knob 16. Post 18 of knob 16 extends slightly into the interior of slide 30 and is rigidly affixed thereto so that the knob 16 can be grasped by the user and moved within slot 20 to thereby move the slide 30 within the housing 12. In an alternate embodiment, the knob 16 is snap-fit into the aperture 39.

Slide 30 includes a first engagement member 32 at one end and a second engagement member 34 at the opposite end, each of which provides a snap fit feature. In the initial neutral position of FIGS. 1 and 2, slide 30 is positioned within housing 10 such that both the first and second engagement members 32, 34 are contained substantially within the housing 12. In this position, both engagement members 32, 34 are in their non-engageable position, which corresponds to a retracted position in the illustrated embodiment. When knob 16 is moved in one direction, e.g., the direction of the arrow for a femoral approach, the slide 30 is moved in the same direction to advance the first engagement member 32 from a first non-engageable, e.g. retracted, position in the housing 12 to a first engageable, e.g. extended, position so the first snap fit feature is exposed. When the knob 16 is moved in the opposite or second direction, e.g., the direction of the arrow for jugular approach, the slide 30 is moved in this second direction to advance the second engagement member 34 from the first non-engageable, e.g. retracted, position in the housing 12 to a second engageable, e.g. extended, position so the second snap fit feature is exposed. The radial components of the slot 20 function to retain the knob 16 and post 18 in the first or second extended position. Furthermore, detent 25 (see FIG. 4) helps maintain the knob 16 in the neutral position (corresponding to the retracted position of the engagement members) by requiring overriding a predetermined force to move the knob. Other retention structure for the knob 16 is also contemplated such as a tapered region.

The vessel filter is contained in tube 40. This tube 40 is positioned in the longitudinal opening extending through slide 30 and is fixedly secured within slide 30 by adhesive so it moves as the slide 30 moves. In an alternate embodiment, slide 30 is insert molded over tube 40. When slide 30 is moved in a femoral direction by knob 16, the first end portion 42 of tube 40 is extended from a first end of housing 12 (see e.g., FIG. 7). When slide 30 is moved in the opposite jugular direction, second end portion 44 is extended from a second end of housing 12 (see e.g., FIGS. 9 and 10). The extended tube portions 42, 44 also provide a guide for cartridge connection as they extend into the hub opening (described below). A pusher of the delivery system, described below, engages the filter to advance it from the tube 40 along the delivery tube of the delivery system for deployment in the vessel.

With reference to FIGS. 5-7, the cartridge 10 is mounted to the hub component 102 of the introducer sheath 101 of the delivery system. The pusher component of the delivery system is designated by reference numeral 110. The pusher 110 has a pusher tube 112 and a wire 113, which can be made of Nitinol, extending from the pusher tube 112. The wire 113 extends through the cartridge 10 and through the length of delivery tube 106 of introducer sheath 101 to maintain a separation of the retention hooks of the filter during insertion of the delivery system and delivery of the filter through tube 106. A conical tube 119 is placed over the free end of tube 40 and snap fitted onto the free engagement member, i.e. the engagement member which is not engaged with the hub, to provide a lead in for the wire 113 to aid insertion as the opening in the tube 119 is aligned with the opening in tube 40. As shown, the snap-fit engagement of the snap fit feature of the engagement member 32 (or 34) of the cartridge 10 within wall 104 of opening 105 of proximal cap 109 connects the cartridge 10 to the delivery system, i.e. the introducer sheath 101. Other modes of attachment are also contemplated. Markings “jugular” and “femoral” on the outer surface of the housing 12 indicate a femoral or jugular direction so the user knows the orientation to attach the cartridge 10 to hub 102, i.e., whether snap-fit feature of engagement member 32 or 34 should be exposed and engaged. FIG. 7 illustrates snap-fit feature of engagement member 32 engaged with hub 102 for providing femoral insertion; FIG. 9 illustrates snap-fit feature of engagement member 34 engaged with hub 102 for providing jugular insertion. As shown, in FIG. 7 knob 16 has been moved from its neutral position to its femoral position; in FIG. 9 knob 16 has been moved from its neutral position to its jugular position.

Once the cartridge 10 is attached, advancement of the pusher 110 advances pusher tube (or rod) 112, to advance the filter from the cartridge 10 and through tube 106 as the distal edge 114 of the pusher tube 112 abuts the proximal end of the filter, with the wire 113 preventing entanglement of the retention hooks. The wire 113 also provides support (stability) for the pusher 110 as the pusher 110 is advanced over the wire. Once the filter is positioned adjacent the opening 108 of delivery tube 106, the introducer sheath 101 is retracted to release the filter through the distal end opening 108 of the tube 106. A visual indicator, e.g. a ring, (not shown) could be provided on the pusher tube 112 to indicate when the filter is adjacent the opening 108 so the user knows not to advance the pusher tube 112 further. Port 107 in hub 102 provides an inlet for attachment of a tube for infusion of cold saline as described in more detail below.

Various filters can be utilized with the cartridge of the present invention. These filters are designed for placement within the inferior vena cava to capture blood clots or other particles which could otherwise pass to the lungs. The filters are movable from a low profile collapsed configuration to facilitate insertion through the delivery sheath to a larger expanded placement configuration to engage the vessel walls to secure (mount) the filter within the inferior vena cava.

One example of a filter which can be inserted using the cartridge of the present invention is illustrated in FIGS. 12A-12C. This filter is described in detail in pending U.S. patent application Ser. No. 10/889,429, filed Jul. 12, 2004, the entire contents of which are incorporated herein by reference. In this bell shaped filter 900, the elongated struts have a first angled region of interconnecting (connecting) struts 914 a, 914 b in the filtering region 919 and a second angled region of interconnecting (connecting) struts 914 e, 914 f in the mounting region 921 of greater transverse dimension. That is, connecting strut portion 914 a of one strut 914 interconnects with the connecting strut portion 914 b of an adjacent strut at joining region 914 d. This forms closed geometric shapes 925. After convergence of strut portions 914 a, 914 b at joining region 914 d, it transitions into elongated mounting strut portions 914 c which form flared mounting or anchoring region 921. Strut portions 914 e, 914 f form connecting portions to connect adjacent strut portions 914 c as connecting strut 914 e of one strut is connected to connecting strut 914 f of an adjacent strut. Connecting strut portion 914 e on one strut and portion 914 f of another strut converge at end (joining) region 929, as closed geometric shapes 935 are formed.

The filtering region 919 converges at portion 932 into tubular portion 918. The tubular portion 918 is preferably in the form of a retrieval hook 950 as described in the '429 application which has a cut out to expose an annular interior surface to accommodate a portion of a tubular snare sheath

Strut portions 914 c terminate in hooks 940 a, 940 b which lie in the plane of strut 914. Hooks 940 a are larger than hooks 940 b and smaller hooks 940 b nest within larger hooks and are spaced axially (inwardly) of hooks 940 a as well as spaced axially with respect to each other.

FIGS. 13A and 13B illustrate an alternate embodiment of the filter having struts interconnected at the filtering region. This filter is described in detail in the '429 patent application. Bell-shaped filter 700 has a filtering region 719 and a flared anchoring (mounting) region 721 of greater transverse dimension. Filtering region 719 has six struts 714 curving outwardly from tubular portion 718. Two connecting filter struts or strut portions 714 a, 714 b angle way from each other to form closed geometric shapes 725. After convergence of strut portions 714 a, 714 b at joining region 714 d, it transitions into elongated mounting strut portions 714 c which form flared mounting or anchoring region 721. The strut portions 714 c terminate in hooks 740 a, 740 b similar to hooks 940 a, 940 b of FIG. 12. The tubular portion 718 is preferably in the form of a retrieval hook 750 similar to hook 950.

Filters 700 and 900 are preferably manufactured from a cut laser tube of shape memory material, such as Nitinol, a nickel titanium alloy, or elgiloy. The collapsed configuration of the filter reduces the overall profile to facilitate delivery to the site. The diameter or transverse dimension of the filter in the collapsed configuration is preferably about 2 mm and more preferably about 1.7 mm. The diameter or transverse dimensions of the filter in the expanded configuration could range from about 18 mm to about 32 mm, depending on the internal diameter of the vessel. To facilitate passage of the filter 700 (or 900) through the lumen of the delivery tube 106, cold saline is injected into the delivery tube 106 (or catheter) around the filter in its collapsed position. The cold saline maintains the temperature dependent filter in a relatively softer condition as it is in the martensitic state within tube 106. This facilitates the exit of the filter from the tube as frictional contact between the filter 10 and the inner surface of the tube would otherwise occur if the filter was maintained in a rigid, i.e. austenitic, condition. Once ejected from tube 106, the filter is no longer cooled and is exposed to the warmer body temperature, which causes the filter 700 (or 900) to return towards its austenitic memorized configuration.

FIGS. 14 and 15 illustrate examples of alternate filters in the prior art that can be inserted using the cartridge of the present invention. In FIG. 14, the filter 400 has two filtering portions 410 and 420. However, the hooks 416 face in the orientation (downstream). If the filter is placed in the incorrect orientation the hooks will not engage. FIG. 14 also shows the filter 400 in the collapsed configuration. In the filter 500 of FIG. 15, the filtering region 510 needs to be positioned to be open in the direction of blood flow. Placement in the incorrect orientation will not enable it to effectively perform its filtering function nor allow its hooks to adequately secure the filter.

FIGS. 8A and 8B illustrate delivery of the filter 900, by way of example, in the inferior vena cava “v” via a femoral approach. Once a femoral approach is decided, the knob 16 of the cartridge 10 is slid in the direction of the femoral arrow to expose the snap fit feature of engagement member 32 (see FIG. 7). It is rotated into the radial slot component 24 to maintain it in place. The cartridge 10 can then be snap fitted onto the hub 102 of introducer 101. (Note the cartridge cannot be snap fitted onto the hub with the knob 16 in the neutral position because the snap fit feature is not sufficiently exposed.) The delivery system is inserted into the femoral vein “f” and advanced through the iliac arteries into the inferior vena cava “v”. Extension 107 of hub 102 receives tubing 350 to enable saline injection. The pusher 110 is advanced so filter 900 is advanced from cartridge 10 by pusher tube 114 and through tubing 106 of sheath 101, to a position adjacent tube opening 108. The introducer sheath is then withdrawn so the filter exits through opening 108, exposing the filter 900 to enable it to be warmed by body temperature to transition to the expanded placement configuration. Note it is implanted in the orientation such that filter section 919 is downstream of the flared anchoring section 921 as shown in FIG. 8B. This enables blood clots or other particles to be directed to the center of the filter section by the angled struts. Thus, correct orientation of filter placement can be appreciated.

FIG. 11 illustrates insertion of filter 900, by way of example, through the internal jugular vein into the inferior vena cava “v”. Once a jugular approach is determined, knob 16 is slid along axial slot 20 in the direction of the jugular arrow to expose the snap fit feature of the engagement member 34 (see e.g., FIGS. 9 and 10). Knob 16 is then rotated into the second radial component 26 to retain the snap feature of engagement member 34 in the extended (exposed) position. The snap feature is then connected to the hub 102 of the introducer sheath component of the delivery system and the pusher tube 114 of pusher 110 advances the filter through tube 106 of sheath 101 as described above to a position adjacent opening 108. Withdrawal of sheath 101 exposes the filter to warmer body temperature where it transitions to the expanded configuration. Note that as implanted, filter section 919 is downstream of flared anchoring section 921.

As an alternative to the withdrawal of the introducer sheath as described in the foregoing methods, pusher 112 could advance the filter from delivery tube 106 and through the opening into the vessel.

Note the other filters described herein could be inserted in the same manner as described above via a femoral or jugular approach.

The filters 700 and 900 can be removed from access through the internal jugular vein or femoral vein. Various methods can be used to remove the filter such as those described in commonly assigned co-pending application serial Ser. No. 09/911,097, filed Jul. 23, 2001, now published application 2002-0193827-A1, published Dec. 19, 2001, the entire contents of which is incorporated herein by reference, including, for example, slotted hooks, graspers, etc. For example, the recess or cutout in the tubular end portions of filters 700 and 900 receive a snare or other device for removal. Filter 400 can also be removed.

Cold saline is injected during the removal process to cool the filters 700 and 900 to change the temperature to transition to a softer martensitic state to facilitate removal. That is, injection of cold saline will cause the filter to approach its martensitic state, bringing the filter to a more flexible condition. The flexible condition facilitates the collapse and withdrawal of the filter into the retrieval sheath by decreasing the frictional contact between the filter and the inner surface of the retrieval sheath.

While the above description contains many specifics, those specifics should not be construed as limitations on the scope of the disclosure, but merely as exemplifications of preferred embodiments thereof. For example, the filters can be inserted in other regions of the body. Also, the cartridge can be used to load other vascular devices. Those skilled in the art will envision many other possible variations that are within the scope and spirit of the disclosure as defined by the claims appended hereto. 

1. A cartridge for holding a vessel filter and connectable to a component of a delivery system, the delivery system delivering the vessel filter to a patient, the cartridge comprising a housing having a first end and a second end, a vessel filter having a plurality of filter legs positioned in the housing, and a first engagement member positioned within the housing and slidable with respect to the housing between a first non-engageable position and a second engageable position for attachment to the delivery system in a first orientation such that the vessel filter can be delivered from the cartridge to the delivery system as it is movable through a first opening in the first engagement member, and a slidable control member including a control knob positioned intermediate the first and second ends and extending transversely through the housing and operatively associated with the first engagement members the control knob movable from a position between the first and second ends toward the first end to slide the first engagement member from within the housing between the first non-engageable position and the second engageable position, and a second engagement member positioned within the housing and movable from a third non-engageable position to a fourth engageable position to engage the component of the delivery system to connect the cartridge to the component in a second orientation such that the vessel filter can be delivered from the cartridge to the delivery system as it is movable through a second opening in the second engagement member.
 2. The cartridge of claim 1, wherein the control member is movable from between the first and second ends toward the first end in a first direction to move the first engagement member to the first engageable position to connect the cartridge in the first orientation and movable from between the first and second ends toward the second end in a second different direction to move the second engagement member to the second engageable position to connect the cartridge in the second orientation.
 3. The cartridge of claim 1, wherein the control member comprises a post movable within an opening in the housing.
 4. The cartridge of claim 3, wherein the opening in the housing includes retention structure to retain the post in a neutral position corresponding to a first non-engageable position of the first engagement member.
 5. The cartridge of claim 3, wherein the opening has an axial component and a radial component, the post positioned in the radial component to retain the engagement member in the first engageable position.
 6. The cartridge of claim 1, wherein the first engagement member includes a snap fit feature exposed in the first engageable position to snap fit with the component of the delivery system.
 7. The cartridge of claim 1, wherein the first and second engagement members are on opposing end portions of a sliding member positioned within the housing.
 8. A vessel filter delivery system comprising: a) a cartridge having a housing having a first end corresponding to a jugular delivery orientation and a second end corresponding to a femoral delivery orientation, the housing dimensioned for retaining a vessel filter the housing having a first diameter; a first engagement member having a first opening for the vessel filter and slidable with respect to the housing to a first engageable position for connection of the cartridge for jugular delivery orientation, the first engagement member having a diameter less than the diameter of the housing; a second engagement member having a second opening for the vessel filter and slidable with respect to the housing to a second engageable position for connection of the cartridge for femoral delivery orientation, the second engagement having a diameter less than the diameter of the housing; a slidable control member positioned intermediate the first and second ends and extending transversely into the housing for sliding the respective engagement member to the engageable position, the control member movable from between the first and second ends toward the first end to slide the first engagement member to the first engageable position and movable from between the first and second ends toward the second end to slide the second engagement member to the second engageable position: b) a vessel filter positioned within the cartridge; c) a delivery tube: and d) a pusher for advancing the vessel filter from the cartridge and through the respective opening of the engagement member and through the delivery tube.
 9. The delivery system of claim 8, further comprising indicia on the housing to indicate the femoral and jugular delivery orientations.
 10. The delivery system of claim 8, further comprising a wire extending from the pusher, the wire separating retention hooks of the filter during delivery.
 11. The cartridge of claim 8, wherein each engagement member has a snap fit feature for connection of the cartridge in the engageable position.
 12. The cartridge of claim 8, wherein the slidable control member has a post movable within an opening formed in the housing.
 13. The cartridge of claim 12, further comprising retention structure to retain the post in at least one of the positions of the engagement member. 